Article
Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease.
Breast cancer research and treatment - 1 Feb 2020
Adhikary Sabina, Hoskin Tanya L, Stallings-Mann Melody L, Arshad Muhammad, Frost Marlene H, Winham Stacey J, Peña Alvaro, Lee Delphine J, Murphy Linda M, Rakoff Michele, Denison Lori A, Knutson Keith L, Radisky Derek C, Visscher Daniel W, Degnim Amy C
Abstract excerpt
PURPOSE: We quantified cytotoxic T cells in nonmalignant breast tissues from women with and without subsequent breast cancer to assess evidence of whether immunosurveillance may be suppressed prior to tumor development. METHODS: We used an age-matched set of breast tissues from women with benign breast disease (BBD) who subsequently developed breast cancer (BBD with later BC), women with BBD who remained cancer...
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