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Article

The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2018

Johansson Bente B, Fjeld Karianne, El Jellas Khadija, Gravdal Anny, Dalva Monica, Tjora Erling, Ræder Helge, Kulkarni Rohit N, Johansson Stefan, Njølstad Pål R, Molven Anders

Abstract excerpt

The enzyme carboxyl ester lipase (CEL), also known as bile salt-dependent or -stimulated lipase (BSDL, BSSL), hydrolyzes dietary fat, cholesteryl esters and fat-soluble vitamins in the duodenum. CEL is mainly expressed in pancreatic acinar cells and lactating mammary glands. The human CEL gene resides on chromosome 9q34.3 and contains a variable number of tandem repeats (VNTR) region that encodes a mucin-like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29233499
DOI: 10.1016/j.pan.2017.12.001

Genes

CEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.PMID 29233499Read ↗

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.Semantic proximity Read ↗

Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas.Semantic proximity Read ↗

The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity.Semantic proximity Read ↗

The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase ( <i>CEL</i> ) gene determines pathogenicitySemantic proximity Read ↗

Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes.Semantic proximity Read ↗

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.Semantic proximity Read ↗

Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding.Semantic proximity Read ↗

Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis.Semantic proximity Read ↗

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease.Semantic proximity Read ↗

The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice.Semantic proximity Read ↗

A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis.Semantic proximity Read ↗

Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells.Semantic proximity Read ↗

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