Article
Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young).
PloS one - 1 Jan 2013
Ræder Helge, Vesterhus Mette, El Ouaamari Abdelfattah, Paulo Joao A, McAllister Fiona E, Liew Chong Wee, Hu Jiang, Kawamori Dan, Molven Anders, Gygi Steven P, Njølstad Pål R, Kahn C Ronald, Kulkarni Rohit N
Abstract excerpt
BACKGROUND: CEL-MODY is a monogenic form of diabetes with exocrine pancreatic insufficiency caused by mutations in CARBOXYL-ESTER LIPASE (CEL). The pathogenic processes underlying CEL-MODY are poorly understood, and the global knockout mouse model of the CEL gene (CELKO) did not recapitulate the disease. We therefore aimed to create and phenotype a mouse model specifically over-expressing mutated CEL in the...
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