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Article

STINGing the immune system: lessons learned through a model of G34-mutant pediatric high-grade glioma.

The Journal of clinical investigation - 15 Nov 2022

Hall Connor P, Cronk James C, Rubens Jeffrey A

Abstract excerpt

Pediatric high-grade gliomas (pHGGs) are aggressive diseases with poor outcomes. The diverse molecular heterogeneity in these rare tumors and inadequate tumor models have limited the development of effective therapies. In this issue of the JCI, Haase et al. produced a genetically engineered mouse model of H3.3-G34R-mutant pHGG to help identify vulnerabilities in DNA repair pathways. The authors designed a therapy...

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Identifiers

PMID: 36377657
DOI: 10.1172/JCI164420
PMCID: PMC9663148

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