Article
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.
Brain : a journal of neurology - 1 Jan 2020
Taguchi Tomoyuki, Ikuno Masashi, Hondo Mari, Parajuli Laxmi Kumar, Taguchi Katsutoshi, Ueda Jun, Sawamura Masanori, Okuda Shinya, Nakanishi Etsuro, Hara Junko, Uemura Norihito, Hatanaka Yusuke, Ayaki Takashi, Matsuzawa Shuichi, Tanaka Masaki, El-Agnaf Omar M A, Koike Masato, Yanagisawa Masashi, Uemura Maiko T, Yamakado Hodaka, Takahashi Ryosuke
Abstract excerpt
Parkinson's disease is one of the most common movement disorders and is characterized by dopaminergic cell loss and the accumulation of pathological α-synuclein, but its precise pathogenetic mechanisms remain elusive. To develop disease-modifying therapies for Parkinson's disease, an animal model that recapitulates the pathology and symptoms of the disease, especially in the prodromal stage, is indispensable. As...
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