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Article

The overexpression of KIT proto-oncogene in acute leukemic cells is not necessarily caused by the gene mutation.

Acta haematologica - 1 Jan 2015

Szatkowski Damian, Hellmann Andrzej

Abstract excerpt

KIT is detected in a variety of cells, also in acute leukemia. Inhibition of wild-type KIT is not always satisfactory. The aim of this work was to evaluate the frequency of the most common KIT mutations in acute myeloid leukemia (AML) and determine the correlation between mutation and expression level. Samples were obtained from 75 patients with AL. CD117 presence was shown in 45 of 51 patients with AML and in 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

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Share to Proto-Oncogene Proteins c-kit

Source

Identifiers

PMID: 25247397
DOI: 10.1159/000360214

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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