Article
Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis.
Scientific reports - 9 Nov 2022
Van Egeren Debra, Kohli Khushi, Warner Jeremy L, Bedard Philippe L, Riely Gregory, Lepisto Eva, Schrag Deborah, LeNoue-Newton Michele, Catalano Paul, Kehl Kenneth L, Michor Franziska
Abstract excerpt
Patients with non-small cell lung cancer (NSCLC) who have distant metastases have a poor prognosis. To determine which genomic factors of the primary tumor are associated with metastasis, we analyzed data from 759 patients originally diagnosed with stage I-III NSCLC as part of the AACR Project GENIE Biopharma Collaborative consortium. We found that TP53 mutations were significantly associated with the development...
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