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Article

Optimizing Antibody-Antigen Binding Affinities with the ADAPT Platform.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Sulea Traian, Deprez Christophe, Corbeil Christopher R, Purisima Enrico O

Abstract excerpt

The ADAPT (Assisted Design of Antibody and Protein Therapeutics) platform guides the selection of mutants that improve/modulate the affinity of antibodies and other biologics. Predicted affinities are based on a consensus z-score from three scoring functions. Computational predictions are interleaved with experimental validation, significantly enhancing the robustness of the design and selection of mutants. A key...

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PMID: 36346603
DOI: 10.1007/978-1-0716-2609-2_20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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