Article
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.
The Lancet. Respiratory medicine - 1 Jan 2015
Rautanen Anna, Mills Tara C, Gordon Anthony C, Hutton Paula, Steffens Michael, Nuamah Rosamond, Chiche Jean-Daniel, Parks Tom, Chapman Stephen J, Davenport Emma E, Elliott Katherine S, Bion Julian, Lichtner Peter, Meitinger Thomas, Wienker Thomas F, Caulfield Mark J, Mein Charles, Bloos Frank, Bobek Ilona, Cotogni Paolo, Sramek Vladimir, Sarapuu Silver, Kobilay Makbule, Ranieri V Marco, Rello Jordi, Sirgo Gonzalo, Weiss Yoram G, Russwurm Stefan, Schneider E Marion, Reinhart Konrad, Holloway Paul A H, Knight Julian C, Garrard Chris S, Russell James A, Walley Keith R, Stüber Frank, Hill Adrian V S, Hinds Charles J
Abstract excerpt
BACKGROUND: Sepsis continues to be a major cause of death, disability, and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim of this study was to identify genetic variants that influence sepsis survival. METHODS: We did a genome-wide association study in three independent cohorts of white...
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