Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian randomization and pathway analysis demonstrate shared genetic associations between lupus and coronary artery disease.

Cell reports. Medicine - 15 Nov 2022

Kain Jessica, Owen Katherine A, Marion Miranda C, Langefeld Carl D, Grammer Amrie C, Lipsky Peter E

Abstract excerpt

Coronary artery disease (CAD) is a leading cause of death in patients with systemic lupus erythematosus (SLE). Despite clinical evidence supporting an association between SLE and CAD, pleiotropy-adjusted genetic association studies are limited and focus on only a few common risk loci. Here, we identify a net positive causal estimate of SLE-associated non-HLA SNPs on CAD by traditional Mendelian randomization (MR)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis and Cardiovascular Diseases
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Lipid metabolism and disorders

Share to Lupus Erythematosus, Systemic

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Systemic Lupus Erythematosus Research

Source

Open in PubMed Open full text

Identifiers

PMID: 36334592
DOI: 10.1016/j.xcrm.2022.100805
PMCID: PMC9729823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian randomization and pathway analysis demonstrate shared genetic associations between lupus and coronary artery disease.PMID 36334592Read ↗

Causal relationship between systemic lupus erythematosus and coronary artery disease: Insights from a meta-analysis and Mendelian randomization.Semantic proximity Read ↗

Assessing the causal relationship between immune traits and systemic lupus erythematosus by bi-directional Mendelian randomization analysis.Semantic proximity Read ↗

Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Semantic proximity Read ↗

Potential drug targets for myocardial infarction identified through Mendelian randomization analysis and Genetic colocalization.Semantic proximity Read ↗

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropySemantic proximity Read ↗

Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids.Semantic proximity Read ↗

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropySemantic proximity Read ↗

Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome‐Wide Mendelian Randomization and Colocalization AnalysisSemantic proximity Read ↗

Systemic Lupus Erythematosus and Cardiovascular Disease: A Mendelian Randomization Study.Semantic proximity Read ↗

Causal associations between primary sclerosing cholangitis and systemic lupus erythematosus: Evidence from Mendelian randomization and transcriptomic analyses.Semantic proximity Read ↗

The potential causal association of systemic lupus erythematosus with congestive heart failure in the East Asian population: A two-sample mendelian randomization study.Semantic proximity Read ↗

Mendelian randomization analysis revealed potential causal factors for systemic lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.