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Article

FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer

1 Nov 2022

Abstract excerpt

Prostate cancer adeno-to-neuroendocrine lineage transition has emerged as a mechanism of targeted therapeutic resistance. Identifying the direct molecular drivers and developing pharmacological strategies using clinical-grade inhibitors to overcome lineage transition-induced therapeutic resistance are imperative. Here, using single-cell multiomics analyses, we investigate the dynamics of cellular heterogeneity,...

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Identifiers

PMID: 36332622
DOI: 10.1016/j.ccell.2022.10.011

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