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Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis

1 Dec 2009

Abstract excerpt

The current trend in genome-wide association studies is to identify regions where the true disease-causing genes may lie by evaluating thousands of single-nucleotide polymorphisms (SNPs) across the whole genome. However, many challenges exist in detecting disease-causing genes among the thousands of SNPs. Examples include multicollinearity and multiple testing issues, especially when a large number of correlated...

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PMID: 20018015
DOI: 10.1186/1753-6561-3-s7-s25

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