Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of IQCH causes male infertility in humans and mice.

eLife - 19 Jul 2024

Ruan Tiechao, Zhou Ruixi, Yang Yihong, Guo Junchen, Jiang Chuan, Wang Xiang, Shen Gan, Dai Siyu, Chen Suren, Shen Ying

Abstract excerpt

IQ motif-containing proteins can be recognized by calmodulin (CaM) and are essential for many biological processes. However, the role of IQ motif-containing proteins in spermatogenesis is largely unknown. In this study, we identified a loss-of-function mutation in the novel gene IQ motif-containing H (IQCH) in a Chinese family with male infertility characterized by a cracked flagellar axoneme and abnormal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Infertility, Male
Share to Axoneme

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calmodulin

Share to Mice, Knockout

Share to Mitochondria

Share to Mutation

Share to Spermatogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 39028117
DOI: 10.7554/eLife.88905
PMCID: PMC11259432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of IQCH causes male infertility in humans and mice.PMID 39028117Read ↗

Deficiency of IQCH causes male infertility in humans and miceSemantic proximity Read ↗

IQCN disruption causes fertilization failure and male infertility due to manchette assembly defectSemantic proximity Read ↗

Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure.Semantic proximity Read ↗

Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagellaSemantic proximity Read ↗

Further evidence from DNAH12 supports favorable fertility outcomes of infertile males with dynein axonemal heavy chain gene family variantsSemantic proximity Read ↗

A novel acrosomal protein, IQCF 1, involved in sperm capacitation and the acrosome reactionSemantic proximity Read ↗

The Genetic Defects of N-DRC in Male Infertility.Semantic proximity Read ↗

Association of novel DNAH11 and DNAH 5 variants with oligoasthenoteratozoospermia lead to male infertilitySemantic proximity Read ↗

Association of novel DNAH11 variants with asthenoteratozoospermia lead to male infertilitySemantic proximity Read ↗

Novel compound heterozygous mutations in DNAH1 cause primary infertility in Han Chinese males with multiple morphological abnormalities of the sperm flagella.Semantic proximity Read ↗

IQ motif-containing G (Iqcg) is required for mouse spermiogenesis.Semantic proximity Read ↗

Novel Mutations in DNAH14 Cause Male Infertility with Small Head SpermSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.