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Molecular insights into sperm head shaping and its role in human male fertility

3 Mar 2025

Abstract excerpt

BACKGROUND: Sperm head shaping, controlled by the acrosome-acroplaxome-manchette complex, represents a significant morphological change during spermiogenesis and involves numerous proteins expressed in a spatially and temporally specific manner. Defects in sperm head shaping frequently lead to teratozoospermia concomitant with oligozoospermia and asthenozoospermia, but the pathogenic mechanism underlying sperm...

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PMID: 40037590
DOI: 10.1093/humupd/dmaf003

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