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Article

Novel NUP210L Variants Cause Fertilization Failure and Male Infertility in Humans.

Clinical genetics - 1 Aug 2026

Ren Keyu, Shen Gan, Ma Han, Zheng Yantong, Zhang Yingteng, Jiang Chuan, Yang Yihong, Wang Xiang, Shen Ying

Abstract excerpt

Fertilization failure remains a major cause of infertility and poor outcomes in assisted reproductive technology, yet the underlying genetic mechanisms are incompletely understood. In this study, we investigated two unrelated infertile men presenting with macrozoospermia and recurrent fertilization failure following intracytoplasmic sperm injection (ICSI). Whole-exome sequencing identified biallelic variants in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42055687
DOI: 10.1111/cge.70175

Genes

NUP210L
PRM1
PRM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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