Article
Revertant somatic mosaicism as a cause of cancer.
Cancer science - 1 Apr 2021
Inaba Toshiya, Nagamachi Akiko
Abstract excerpt
Revertant (somatic) mosaicism is a spontaneous correction of a causative mutation in patients with congenital diseases. A relatively frequent event, revertant mosaicism may bring favorable outcomes that ameliorate disorders, and is therefore called "natural gene therapy." However, it has been revealed recently that "overcorrection" of inherited bone marrow failure in patients with sterile alpha motif domain...
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