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Article

A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer

31 Oct 2022

Abstract excerpt

BackgroundNeuroendocrine prostate cancer (NEPC) is an aggressive subtype, the presence of which changes the prognosis and management of metastatic prostate cancer.MethodsWe performed analytical validation of a Circulating Tumor Cell (CTC) multiplex RNA qPCR assay to identify the limit of quantification (LOQ) in cell lines, synthetic cDNA, and patient samples. We next profiled 116 longitudinal samples from a...

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PMID: 36317634
DOI: 10.1172/jci161858

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