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Article

Challenged Urine Bicarbonate Excretion as a Measure of Cystic Fibrosis Transmembrane Conductance Regulator Function in Cystic Fibrosis.

Annals of internal medicine - 1 Nov 2022

Berg Peder, Sorensen Mads V, Rousing Amalie Quist, Vebert Olesen Hanne, Jensen-Fangel Søren, Jeppesen Majbritt, Leipziger Jens

Abstract excerpt

BACKGROUND: In cystic fibrosis (CF), renal base excretion is impaired. Accordingly, challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function. OBJECTIVE: To evaluate the association between challenged bicarbonate excretion and clinical characteristics at baseline, quantify the CFTR modulator drug...

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Source

Identifiers

PMID: 36315944
DOI: 10.7326/M22-1741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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