Article
Pancreatic Cancer Research beyond DNA Mutations.
Biomolecules - 17 Oct 2022
Sato Hiromichi, Sasaki Kazuki, Hara Tomoaki, Tsuji Yoshiko, Arao Yasuko, Otsuka Chihiro, Hamano Yumiko, Ogita Mirei, Kobayashi Shogo, di Luccio Eric, Hirotsu Takaaki, Doki Yuichiro, Eguchi Hidetoshi, Satoh Taroh, Uchida Shizuka, Ishii Hideshi
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is caused by genetic mutations in four genes: KRAS proto-oncogene and GTPase (KRAS), tumor protein P53 (TP53), cyclin-dependent kinase inhibitor 2A (CDKN2A), and mothers against decapentaplegic homolog 4 (SMAD4), also called the big 4. The changes in tumors are very complex, making their characterization in the early stages challenging. Therefore, the development of...
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