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Pre-and Postoperative Circulating Tumour DNA in Patients With Gastrointestinal Stromal Tumour - A Methodological Assessment Study.

Anticancer research - 1 Nov 2022

Brinch Charlotte Margareta, Aggerholm-Pedersen Ninna, Poulsen Tim Svenstrup, Skovrider-Ruminski Wojciech, DE Heer Pieter, Penninga Luit, Krarup-Hansen Anders, Hogdall Estrid

Abstract excerpt

BACKGROUND/AIM: Gastrointestinal stromal tumours (GISTs) harbour genetic aberrations in receptor tyrosine kinase KIT (KIT) or platelet-derived growth factor receptor A (PDGFRA) in 85-90% of the patients. Circulating tumour DNA (ctDNA) is a potential biomarker in patients with GIST. Previous studies investigating ctDNA around surgery in patients with GIST presented divergent results regarding the proportion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36288871
DOI: 10.21873/anticanres.16022

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