Article
Genomic profiling in GIST: Implications in clinical outcome and future challenges.
Neoplasia (New York, N.Y.) - 1 Feb 2024
Calderillo-Ruíz German, Pérez-Yepez Eloy Andrés, García-Gámez María Alejandra, Millan-Catalan Oliver, Díaz-Romero Consuelo, Ugalde-Silva Paul, Salas-Benavides Rodrigo, Pérez-Plasencia Carlos, Carbajal-López Berenice
Abstract excerpt
Gastrointestinal Stromal Tumors (GIST) are the most frequent mesenchymal neoplasia of the digestive tract. Genomic alterations in KIT, PDFGRA, SDH, and BRAF genes are essential in GIST oncogenesis. Therefore, the mutations in these genes have demonstrated clinical implications. Tumors with deletions in KIT-exon 11 or duplications in exon 9 are associated with a worse prognosis. In contrast, KIT-exon 11...
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