Article
Pretreatment Tumor DNA Sequencing of KIT and PDGFRA in Endosonography-Guided Biopsies Optimizes the Preoperative Management of Gastrointestinal Stromal Tumors.
Molecular diagnosis & therapy - 1 Apr 2020
Hedenström Per, Andersson Carola, Sjövall Henrik, Enlund Fredrik, Nilsson Ola, Nilsson Bengt, Sadik Riadh
Abstract excerpt
BACKGROUND: Neoadjuvant tyrosine kinase inhibitor (TKI) therapy increases the chance of organ-preserving, radical resection in selected patients with gastrointestinal stromal tumors (GISTs). We aimed to evaluate systematic, immediate DNA sequencing of KIT and PDGFRA in pretreatment GIST tissue to guide neoadjuvant TKI therapy and optimize preoperative tumor response. METHODS: All patients who were candidates for...
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