Prospective Study of Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Hepatectomy for Colorectal Liver Metastases.

doi:10.1097/SLA.0000000000005461

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Prospective Study of Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Hepatectomy for Colorectal Liver Metastases.

Annals of surgery - 1 May 2023

Newhook Timothy E, Overman Michael J, Chun Yun Shin, Dasari Arvind, Tzeng Ching-Wei D, Cao Hop S Tran, Raymond Victoria, Parseghian Christine, Johnson Benny, Nishioka Yujiro, Kawaguchi Yoshikuni, Uppal Abhineet, Vreeland Timothy J, Jaimovich Ariel, Arvide Elsa M, Cristo Jenilette V, Wei Steven H, Raghav Kanwal P, Morris Van K, Lee Jeffrey E, Kopetz Scott, Vauthey Jean-Nicolas

Abstract excerpt

OBJECTIVE: To evaluate the association of perioperative ctDNA dynamics on outcomes after hepatectomy for CLM. SUMMARY BACKGROUND DATA: Prognostication is imprecise for patients undergoing hepatectomy for CLM, and ctDNA is a promising biomarker. However, clinical implications of perioperative ctDNA dynamics are not well established. METHODS: Patients underwent curative-intent hepatectomy after preoperative...

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PMID: 35797554
DOI: 10.1097/SLA.0000000000005461

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