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Article

Detection of mutant free circulating tumor DNA in the plasma of patients with gastrointestinal stromal tumor harboring activating mutations of CKIT or PDGFRA.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2013

Maier Jacqueline, Lange Thoralf, Kerle Irina, Specht Katja, Bruegel Melanie, Wickenhauser Claudia, Jost Philipp, Niederwieser Dietger, Peschel Christian, Duyster Justus, von Bubnoff Nikolas

Abstract excerpt

PURPOSE: In gastrointestinal stromal tumor (GIST), there is no biomarker available that indicates success or failure of therapy. We hypothesized that tumor-specific v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (CKIT)- or platelet-derived growth factor receptor-α (PDGFRA)-mutant DNA fragments can be detected and quantified in plasma samples of patients with GIST. EXPERIMENTAL DESIGN: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

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Source

Identifiers

PMID: 23833305
DOI: 10.1158/1078-0432.CCR-13-0765

Genes

PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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