Article

C698R Lrsam1 knock-in mouse model for CMT2P

2022-04-01

Abstract excerpt

<h4>Objective: </h4> Missense mutation C694R in the RING domain of the LRSAM1 gene results in a dominantly inherited peripheral neuropathy, Charcot-Marie-Tooth disease type 2P (CMT2P). In this study, we have generated a Lrsam1 C698R knock-in mouse model, which was extensively characterized. <h4>Methods: </h4>: Mice with a heterozygous Lrsam1 +/ C698R mutation were generated by CRISPR/Cas9 technology. The C698R Lrs...

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Literature Corpus work: 343d1bfe-fd0f-5d4a-a126-57b66ed83b1c
DOI: 10.21203/rs.3.rs-1482385/v1

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