Article
[Li-Fraumeni syndrome in adult patients with acute lymphoblastic leukemia].
Terapevticheskii arkhiv - 23 Jul 2021
Zarubina K I, Parovichnikova E N, Surin V L, Pshenichnikova O S, Gavrilina O A, Isinova G A, Troitskaya V V, Sokolov A N, Galtseva I V, Kapranov N M, Davydova J O, Obukhova T N, Nikulina E E, Sudarikov A B, Savchenko V G
Abstract excerpt
BACKGROUND: LiFraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary disorder that is characterized by an increased risk for certain types of cancer, acute lymphoblastic leukemia (ALL), particularly. Germline TP53 mutations are associated with LFS. Genetic counseling and follow-up is essential for patients with LFS and their relatives. Special therapeutic approaches are needed for treatment of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.