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Article

Hematologic malignancies in Li-Fraumeni syndrome: A case report.

American journal of medical genetics. Part A - 1 Jul 2024

Bundrant Bethany, Gerstein Yoheved, Arun Banu, DiNardo Courtney D

Abstract excerpt

Li-Fraumeni syndrome (LFS) is a rare syndrome characterized by an increased lifetime risk of cancer development in multiple organ systems, typically caused by de novo or inherited germline pathogenic variants in the tumor suppressor TP53 gene. LFS is more classically associated with solid tumors; however, it is also associated with hematologic malignancies such as therapy-related acute myeloid leukemia (AML). We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38410872
DOI: 10.1002/ajmg.a.63573

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