Article
Pediatric cancer and Li-Fraumeni/Li-Fraumeni-like syndromes: a review for the pediatrician.
Revista da Associacao Medica Brasileira (1992) - 1 Jan 2000
Giacomazzi Cristina Rossi, Giacomazzi Juliana, Netto Cristina B O, Santos-Silva Patricia, Selistre Simone Geiger, Maia Ana Luiza, Oliveira Viviane Ziebell de, Camey Suzi Alves, Goldim José Roberto, Ashton-Prolla Patricia
Abstract excerpt
INTRODUCTION: cancer is the second leading cause of death in children between the ages of 0 and 14 years, corresponding to approximately 3% of all cases diagnosed in Brazil. A significant percentage (5-10%) of pediatric cancers are associated with hereditary cancer syndromes, including Li-Fraumeni/Li-Fraumeni-like syndromes (LFS/LFL), both of which are caused by TP53 germline mutations. Recent studies have shown...
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