Article
The evaluation of the possibility of Li-Fraumeni syndrome in cancer patients in East Azarbaijan Province of Iran.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2024
Esmaeilzadeh Aghjeh Maryam, Hosseinpour Feizi Mohammad Ali, Safaralizadeh Reza, Hosseinpour Feizi Abbas Ali, Pouladi Nasser
Abstract excerpt
INTRODUCTION: In 1969, Li-Fraumeni syndrome (LFS), which is a rare cancer predisposition syndrome, was reported for the first time. The main problem in LFS is the mutation in the TP53 gene, which is a crucial tumor suppressor gene in the cell cycle. A hereditary syndrome is inherited in an autosomal dominant pattern. There is a significant correlation between this syndrome and various cancers such as sarcoma,...
Topics
- Child
- Humans
- Li-Fraumeni Syndrome
- Genes, p53
- Iran
- Tumor Suppressor Protein p53
- Germ-Line Mutation
- Genetic Predisposition to Disease