Article
Gene expression-based dissection of inter-histotypes, intra-histotype and intra-tumor heterogeneity in pediatric tumors.
Scientific reports - 25 Oct 2022
Ciceri Sara, Carenzo Andrea, Iannó Maria Federica, Bertolotti Alessia, Morosi Carlo, Luksch Roberto, Spreafico Filippo, Collini Paola, Radice Paolo, Massimino Maura, De Cecco Loris, Perotti Daniela
Abstract excerpt
Intra-tumor heterogeneity (ITH) fosters tumor evolution, resistance to therapy, and relapse. Recently, many evidence have been accumulated on the occurrence of genetic ITH in pediatric cancers. With this study we aimed to address the downstream effects that genetic and epigenetic ITH, and tumor-microenvironment interactions may produce within a tumor mass. To this aim, we investigated by high-throughput gene...
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