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The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A1-A2A receptor heteromer formation and function.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2022

Sarasola Laura I, Del Torrent Claudia Llinas, Pérez-Arévalo Andrea, Argerich Josep, Casajuana-Martín Nil, Chevigné Andy, Fernández-Dueñas Víctor, Ferré Sergi, Pardo Leonardo, Ciruela Francisco

Abstract excerpt

Adenosine modulates neurotransmission through inhibitory adenosine A1 receptors (A1Rs) and stimulatory A2A receptors (A2ARs). These G protein-coupled receptors are involved in motor function and related to neurodegenerative diseases such as Parkinson's disease (PD). An autosomal-recessive mutation (G2797.44S) within the transmembrane helix (TM) 7 of A1R (A1RG279S) has been associated with the development of early...

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PMID: 36279718
DOI: 10.1016/j.biopha.2022.113896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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