Article
High-level copy number gains of established and potential drug target genes in gastric cancer as a lead for treatment development and selection.
Cellular oncology (Dordrecht, Netherlands) - 1 Feb 2014
Labots Mariette, Buffart Tineke E, Haan Josien C, van Grieken Nicole C T, Tijssen Marianne, van de Velde Cornelis J H, Grabsch Heike I, Ylstra Bauke, Carvalho Beatriz, Fijneman Remond J A, Verheul Henk M W, Meijer Gerrit A
Abstract excerpt
PURPOSE: The overall survival rate of patients with advanced gastric cancer is poor. Therefore, there is an urgent need for new treatment options for these patients. The identification of drug target genes located on DNA regions exhibiting high-level copy number gains (CNG) may be an effective approach, as has e.g. previously been shown for HER2. The aim of the present study was to identify putative drug targets...
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