Article
Induction of micronuclei in murine lymphocytes by morphine.
Environmental and molecular mutagenesis - 1 Jan 1995
Sawant S G, Couch D B
Abstract excerpt
Although individuals who abuse drugs are prone to an increased risk of malignancy, the mutagenic and carcinogenic potential of these agents has received relatively little attention. We report here on the potential of morphine to induce micronuclei in murine lymphocytes. Following a single intraperitoneal injection of 20 mg/kg morphine, the frequency of micronucleated binuclear (cytochalasin-blocked) murine T- and...
Topics
- Analysis of Variance
- Animals
- B-Lymphocytes
- DNA Damage
- Dose-Response Relationship, Drug
- Female
- Injections, Intraperitoneal
- Mice
- Mice, Inbred C57BL
- Micronucleus Tests
- Morphine
- Mutagens