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The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling

21 Oct 2022

Abstract excerpt

Influenza A virus (IAV) polymerase protein PB2 has been shown to partially inhibit the host immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 protein that regulates the downstream signaling pathway of IFNs is not well characterized. Here, we report that IAV PB2 protein reduces cellular sensitivity to IFNs, suppressing the activation of STAT1/STAT2 and ISGs. Furthermore, IAV PB2...

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PMID: 36271046
DOI: 10.1038/s41467-022-33909-2

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