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Article

The influenza virus PB1-F2 protein has interferon antagonistic activity

4 Nov 2011

Abstract excerpt

PB1-F2 is a nonstructural protein of influenza viruses encoded by the PB1 gene segment from a +1 open reading frame. It has been shown that PB1-F2 contributes to viral pathogenicity, although the underlying mechanisms are still unclear. Induction of type I interferon (IFN) and the innate immune response are the first line of defense against viral infection. Here we show that influenza A viruses (IAVs) lacking the...

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Identifiers

PMID: 22050228
DOI: 10.1515/bc.2011.174

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