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Pirh2 restricts influenza A virus replication by modulating short‐chain ubiquitination of its nucleoprotein

7 Sept 2022

Abstract excerpt

Influenza A viruses (IAVs) rely on viral ribonucleoprotein (vRNP) complexes to control transcription and replication. Each vRNP consists of one viral genomic RNA segment associated with multiple nucleoproteins (NP) and a trimeric IAV RNA polymerase complex. Previous studies showed that post-translational modifications of vRNP components, such as NP, by host factors would in turn affect the IAV life cycle or...

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PMID: 36070077
DOI: 10.1096/fj.202200473r

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