Article
Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Feb 2013
Oxnard Geoffrey R, Lo Peter C, Nishino Mizuki, Dahlberg Suzanne E, Lindeman Neal I, Butaney Mohit, Jackman David M, Johnson Bruce E, Jänne Pasi A
Abstract excerpt
INTRODUCTION: Exon 20 insertions are the third most common family of epidermal growth factor receptor (EGFR) mutations found in non-small-cell lung cancer (NSCLC). Little is known about cancers harboring these mutations aside from their lack of response to EGFR tyrosine kinase inhibitors, impairing the development of effective targeted therapies. METHODS: NSCLC patients with EGFR genotyping were studied using a...
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