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An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas

20 Oct 2022

Abstract excerpt

A third of patients with diffuse large B-cell lymphoma (DLBCL) present with extranodal dissemination, which is associated with inferior clinical outcomes. MYD88L265P is a hallmark extranodal DLBCL mutation that supports lymphoma proliferation. Yet extranodal lymphomagenesis and the role of MYD88L265P in transformation remain mostly unknown. Here, we show that B cells expressing Myd88L252P (MYD88L265P murine...

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PMID: 36264161
DOI: 10.1158/2159-8290.cd-22-0561

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