Genetically driven immune microenvironment states associate with therapeutic responses in MYD88 mutant lymphomas.

doi:10.1186/s12943-026-02646-1

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Article

Genetically driven immune microenvironment states associate with therapeutic responses in MYD88 mutant lymphomas.

Molecular cancer - 20 Apr 2026

Celay Jon, Recalde Miriam, Revuelta Maria V, Larrayoz Marta, Vicente Carmen, Lozano Teresa, Gil Carmen, Chapman Jennifer R, Garcia-Lacarte Marcos, Gonzalez Carmen, Ariceta Beñat, Rodriguez Sara, Lasa Marta, Garcia-Barchino Maria J, Fresquet Vicente, Jimenez Maddalen, Sanz Sonia, Du Ming-Qing, Roncador Giovanna, Vega Zaira, Sacco Antonio, Roccaro Aldo, Knittel Gero, Reinhardt Hans Christian, Piazza Rocco, Herter Sylvia, Goodhew Rebecca, Caron Jonathan, Roos-Weil Damien, Miguel Jesus San, Canales Miguel, Hodson Daniel J, Lossos Izidore S, Lasarte Juan J, Roa Sergio, Prosper Felipe, Paiva Bruno, Cerchietti Leandro, Martinez-Climent Jose A

Abstract excerpt

The interaction between lymphoma cells and immune microenvironment cells and the impact of this functional interplay on therapeutic responses remain largely unexplored. Here, we utilized murine models with oncogenically active MYD88 and additional genetic lesions co-triggered at selected B cell stages to generate human-like lymphomas harboring the MYD88L265P mutation. Lymphomas exhibited behaviors ranging from...

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Identifiers

PMID: 42010569
DOI: 10.1186/s12943-026-02646-1
PMCID: PMC13501595

Genes

MYD88

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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