Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatment.

doi:10.1182/blood.2024027877

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Article

Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatment.

Blood - 11 Sept 2025

Pelzl Richard J, Benintende Giulia, Gsottberger Franziska, Scholz Julia K, Ruebner Matthias, Yao Hao, Wendland Kerstin, Rejeski Kai, Altmann Heidi, Petkovic Srdjan, Mellenthin Lisa, Kübel Sabrina, Schmiedeberg Moritz, Klein Paulina, Petrera Agnese, Baur Rebecca, Eckstein Sophie, Hoepffner-Grundy Sandra, Röllig Christoph, Subklewe Marion, Huebner Hanna, Schett Georg, Mackensen Andreas, Laurenti Luca, Graw Frederik, Völkl Simon, Nganou-Makamdop Krystelle, Müller Fabian

Abstract excerpt

ABSTRACT: Immunotherapy has become standard of care in the treatment of diffuse large B-cell lymphoma (DLBCL). Changes in immunophenotypes observed at first diagnosis predict therapy outcome but little is known about the resolution of these alterations in remission. Comprehensive characterization of immune changes from fresh, peripheral whole blood revealed a functionally relevant increase of myeloid-derived...

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Identifiers

PMID: 40359478
DOI: 10.1182/blood.2024027877
PMCID: PMC12824679

Genes

CD14

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