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Article

Extranodal involvement defines distinct immune-molecular phenotypes and clinical outcomes in diffuse large b-cell lymphoma.

Clinical and experimental medicine - 26 Jul 2026

Ahongjiang Yiliya, Qiu Lihua, Li Min, Sun Biwen, Zhang Huilai, Tian Chen

Abstract excerpt

Extranodal involvement (ENI) is incorporated into routine risk assessment for diffuse large B-cell lymphoma (DLBCL), but treating ENI as a single binary adverse feature may conceal clinically relevant heterogeneity in extranodal burden, anatomical distribution, treatment feasibility, and immune-molecular context. We evaluated ENI as a burden- and site-aware phenotype rather than as a uniform descriptor. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42565886
DOI: 10.1007/s10238-026-02268-3
PMCID: PMC13451387

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