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Article

Data-independent acquisition-based quantitative proteomic analysis of m.3243A>G MELAS reveals novel potential pathogenesis and therapeutic targets.

Medicine - 14 Oct 2022

Chang Xueli, Yin Zhaoxu, Zhang Wei, Shi Jiaying, Pu Chuanqiang, Shi Qiang, Wang Juan, Zhang Jing, Yan Li, Yang Wenqu, Guo Junhong

Abstract excerpt

The pathogenesis of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS) syndrome has not been fully elucidated. The m.3243A > G mutation which is responsible for 80% MELAS patients affects proteins with undetermined functions. Therefore, we performed quantitative proteomic analysis on skeletal muscle specimens from MELAS patients. We recruited 10 patients with definitive MELAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36254078
DOI: 10.1097/MD.0000000000030938
PMCID: PMC9575705

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