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Data-Independent Acquisition-Based Quantitative Proteomic Analysis of m.3243A>G MELAS Reveals Novel Potential Pathogenesis and Therapeutic Targets

2020-07-02

Abstract excerpt

<h4>Background: </h4> The pathogenesis of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS) syndrome is not completely understood. The m.3243A > G mutation responsible for 80% MELAS patients affects proteins with undetermined functions. Therefore, we performed quantitative proteomic analysis on skeletal muscle specimens from MELAS patients. Methods We recruited 10 patients w...

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Literature Corpus work
5ac19311-9098-521a-84d8-eb0915fa3d3a
DOI
10.21203/rs.3.rs-38357/v1
Open publication

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Data-Independent Acquisition-Based Quantitative Proteomic Analysis of m.3243A&gt;G MELAS Reveals Novel Potential Pathogenesis and Therapeutic TargetsDOI 10.21203/rs.3.rs-38357/v1
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