Article

Integrated Proteomic and Metabolomic Analyses of the Mitochondrial Neurodegenerative Disease MELAS

2021-12-21

Abstract excerpt

<h4>ABSTRACT</h4> MELAS (mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes) is a progressive neurodegenerative disease caused by pathogenic mitochondrial DNA variants. The pathogenic mechanism of MELAS remains enigmatic due to the exceptional clinical heterogeneity and the obscure genotype-phenotype correlation among MELAS patients. To gain insights into the pathogenic signature of MELAS, we...

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Literature Corpus work: 3150b786-d892-55cb-9eab-b6bdbdef2b8b
DOI: 10.1101/2021.12.18.473301

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