Article
Unilateral cryptorchidism in mice mutant for Ptgds.
Human mutation - 1 Feb 2013
Philibert Pascal, Boizet-Bonhoure Brigitte, Bashamboo Anu, Paris Françoise, Aritake Kosuke, Urade Yoshihiro, Leger Juliane, Sultan Charles, Poulat Francis
Abstract excerpt
The pathophysiology of cryptorchidism, abnormal testicular descent, remains poorly understood. In this study, we show that both heterozygous and homozygous mice deficient for lipocalin-type prostaglandin D(2) (PGD(2) ) synthase (Ptgds) presented unilateral cryptorchidism affecting the second phase of testicular descent in 16% and 24% of cases, respectively. The adult cryptorchid testes show an increase in...
Topics
- Androgens
- Animals
- Apoptosis
- Child
- Cryptorchidism
- Humans
- Intramolecular Oxidoreductases
- Lipocalins
- Male
- Mice
- Mutation
- Prostaglandin D2