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Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

15 Oct 2022

Abstract excerpt

In cultured cells, SARS-CoV-2 infects cells via multiple pathways using different host proteases. Recent studies have shown that the furin and TMPRSS2 (furin/TMPRSS2)-dependent pathway plays a minor role in infection of the Omicron variant. Here, we confirm that Omicron uses the furin/TMPRSS2-dependent pathway inefficiently and enters cells mainly using the cathepsin-dependent endocytosis pathway in...

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PMID: 36243815
DOI: 10.1038/s41467-022-33911-8

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