Article

TMPRSS2 is essential for SARS-CoV-2 Beta and Omicron infection

2022-12-09

Abstract excerpt

The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells and TMPRSS2 inhibitors are being developed for COVID-19 therapy. However, the SARS-CoV-2 Omicron variant, which currently dominates the pandemic, prefers the endo/lysosomal cysteine protease cathepsin L over TMPRSS2 for cell entry...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56350f58-89bf-52c1-a1c1-cca57cfd97a4
DOI: 10.1101/2022.12.09.519765

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TMPRSS2 is essential for SARS-CoV-2 Beta and Omicron infectionDOI 10.1101/2022.12.09.519765Read

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airwaysSemantic proximity Read

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19Semantic proximity Read

Comparison of the Pathogenicity of SARS-CoV-2 Delta and Omicron Variants by Analyzing the Expression Patterns of Immune Response Genes in K18-hACE2 Transgenic MiceSemantic proximity Read

SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse modelsSemantic proximity Read

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in miceSemantic proximity Read

Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype MiceSemantic proximity Read

Single-cell transcriptomic atlas of blood and lung from mice infected with SARS-CoV-2 revealing distinct virulence characteristics between prototype and Omicron BA.1 strainSemantic proximity Read

Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2Semantic proximity Read

The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoidsSemantic proximity Read

The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 TreatmentSemantic proximity Read

SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid modelsSemantic proximity Read

Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory miceSemantic proximity Read