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Article

Bi-directional and multivariate mendelian randomization analysis of the relationship between circulating 25-hydroxyvitamin D concentration and obstructive sleep apnea.

BMC pulmonary medicine - 14 Oct 2022

Luo Xi, Chang Ruijing, Zhang Jianli, Jiang Peng, Xu Sicheng

Abstract excerpt

BACKGROUND: 25-hydroxyvitamin D [25(OH)D] deficiency in patients with Obstructive Sleep Apnea (OSA) has long been noted, but identifying the exact causal relationship remains hard. Investigation of the causality between 25(OH)D deficiency and OSA would help facilitate disease prevention. METHODS: We conducted a two-sample bi-directional Mendelian randomization (MR) study. For forward analysis, 237 newly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36241991
DOI: 10.1186/s12890-022-02172-y
PMCID: PMC9569054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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