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Article

Exploring the genetic link between obstructive sleep apnea and obesity: A bidirectional Mendelian randomization study.

Respiratory medicine - 1 Feb 2026

Cai Fuguo, Hong Wei, Xiong Chaoliang, She Ningning, Lu Rui, Shi Yewen, Ren Xiaoyong

Abstract excerpt

BACKGROUND: Obstructive sleep apnea (OSA) and obesity are interrelated conditions with significant public health implications, but the genetic causal association between them remains unclear. This study investigates their bidirectional causality using Mendelian randomization (MR). METHODS: Genetic data for OSA were obtained from the FinnGen consortium, including 38,998 OSA cases and 336,659 controls, as well as a...

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Identifiers

PMID: 41448284
DOI: 10.1016/j.rmed.2025.108609

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