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Article

Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC-MS/MS.

Biomedical chromatography : BMC - 1 Jan 2023

Fu Yuhao, Li Ying, Ma Yinling, He Xueru, Xun Xuejiao, Cui Yanjun, Fan Liju, Dong Zhanjun

Abstract excerpt

Almonertinib was included in the first-line treatment of non-small cell lung cancer with EGFR T790M mutations by the Chinese Society of Clinical Oncology in 2021. Considering that immunocompromised lung cancer patients are prone to opportunistic fungal infections, and most triazole antifungal drugs are moderate or strong inhibitors of CYP3A4, this study was conducted to develop and validate an accurate and rapid...

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Source

Identifiers

PMID: 36241418
DOI: 10.1002/bmc.5525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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